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RegWatch Daily Issue #247 — May 22, 2026
FDA

CDRH finalizes AI/ML SaMD modification guidance. The long-awaited update clarifies when algorithm changes require a new 510(k). Bottom line: performance-only updates with no changed intended use probably don't need submission. Changes to inputs or intended use — that's a different story. Read the full guidance before you ship your next update.

EU MDR

MDCG 2026-4 clarifies post-market surveillance timelines. Notified bodies are now expecting annual PMS reports for Class IIa+ devices, even when no incidents occurred. If your PMS plan still says "as needed," it's time for a rewrite.

QMSR

QMSR transition clock: 16 months remaining. FDA's alignment with ISO 13485:2016 becomes effective February 2027. Companies still running dual QSR/ISO systems need to start their gap assessment now — integration takes time you probably don't have.

Structured, factual, written with a point of view. Not a press release rewrite.

Pattern Recognition

Recalls and warning letters don't happen at random. We track the enforcement signals and tell you when the pattern suggests a coming crackdown in your category.

5-Minute Read

Every briefing fits the time between your coffee and your first meeting. Concise takes, clear hierarchy, no padding. If it can be said in 300 words, we won't use 800.

Verifiable Citations

Every claim links to a CFR section, ISO clause, guidance document, or openFDA entry. We tell you what we know and where to verify it. No vague references.

Plain English

Regulations are written by lawyers for lawyers. We translate what changed, why it matters, and what you need to do about it — before your coffee gets cold.

Six regulatory systems.
One daily briefing.

US

FDA / CDRH

510(k), 513(g), PMA, De Novo, UDI, QMSR, enforcement actions, recall database, guidance documents

EU

EU MDR / IVDR

MDCG guidance, notified body capacity, EUDAMED registration, CE marking timeline changes

ISO

ISO / IEC Standards

ISO 13485, 14971, 62304, 60601 series, new and revised standards with regulatory relevance

UK

MHRA

UKCA marking, UK MDR 2002 post-Brexit updates, MHRA guidance and consultations

CA

Health Canada

MDSAP requirements, Health Canada IVDD/MDD transitions, Class II–IV license updates

JP

PMDA / TGA

Japan's Pharmaceutical and Medical Device Agency, Australia's Therapeutic Goods Administration

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01 Every citation is verifiable. Every claim traces to an official source.
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The people who build medical devices — who design them, validate them, manufacture them, and stand behind them — deserve better than government press releases rewritten by content algorithms. They deserve a briefing written by people who've been in the room. Who know the difference between a 510(k) and a De Novo without having to look it up. Who will tell you when something actually matters and when it's just noise.

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